Synthesis and characterization of polyrotaxane based on mono-6-deoxy-6-(p-tolylsulfonyl)-β-cyclodextrin
발표자
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초록
내용
β-Cyclodextrin(β-CD) is a type of cyclic oligosaccharide used in various fields such as drug delivery, gene therapy, catalyst, chemical sensor, and liquid crystal. Mono-6-deoxy-6-(p-tolylsulfonyl)-β-cyclodextrin (TsO-β-CD) was synthesized by replacing one hydroxyl group among 21 hydroxyl groups in β-CD under various pH conditions using p-toluenesulfonyl chloride(p-TsCl),and used to synthesis polyrotaxane by threading TsO-β-CD on PPG-diamine with a molecular weight of 2000, followed by end capping using Trt-Gly-OH , N-Hydroxysuccinimide (NHS), ethylene dichloride (EDC). The synthesized CD derivatives and polyrotaxane were characterized by 1HNMR and FTIR spectroscopies.