Nitric oxide-mediated mucus-walking zwitterionic polymer nanocomplex for relief of acute respiratory distress syndrome
발표자
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초록
내용
While lung-related diseases are receiving lot of attention due to the recent SARS-CoV-2 pandemic, many studies are being conducted for treating chronic lung disease such as fibrosis and acute respiratory distress syndrome (ARDS). Pulmonary delivery system, despite its advantages such as high drug delivery efficiency and accessibility, it is an ironical system with low drug delivery efficiency due to defensive systems of lungs (e.g. mucus layer, airway macrophage, etc.). In this study, zwitterionic polymer nanocomplex (ZPN) with anti-mucus effect was synthesized, and nitric oxide (NO) capable of anti-inflammation were loaded for ARDS treatment. The NO loaded in ZPN not only has an anti-inflammation effect but also could act as a nanomotor, investigated that Dex/NO-loaded ZPN (ZDN) has high drug delivery efficiency in lungs filled with bronchoalveolar lavage fluid (BALF) by ARDS symptoms through mucus-walking ability. As a result, treating effects such as decreased expression of ARDS-related cytokines and increased survival rate due to ZDN were confirmed.