Protein-like functions of sequence-defined biopolymers for diagnostic and therapeutic applications
발표자
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초록
내용
In nature, sequence-defined biopolymers, such as nucleic acids and amino acids, fold into specific 3D nanostructures, creating a variety of biological functions, including molecular recognition, enzymatic reactions, and even nanomechanical motions. For more useful and sometimes, more complex functionalities, further modifications would be necessary; to ensure the specific 3D folding, the modifications should be controlled over the predetermined sequence of the biopolymers. In this presentation, I will introduce generation of highly functionalized biopolymers and their sequence-controlled modifications, and their complex functionalities, such as induced fit, regioselective conjugation, and ionic flux control, will be demonstrated for diagnostic and therapeutic applications.