Nanopatterned functional polyimide gravimetric sensor based on molecular imprinting for detection of melittin using nanocontact printing
발표자
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초록
내용
In this study, a chalcone branched functional polyimide capable of photodimerization was synthesized by Steglich esterification for use as a melittin-imprinted polymeric material. Based on nanocontact printing using melittin-modified PDMS replica molds, line-patterned molecularly imprinted polymer (L-MIP) films were fabricated on quartz electrode through photo-polymerization. In the rebinding process using quartz crystal microbalance (QCM) in a 10-fold diluted artificial plasma containing of 30 μg/mL melittin, L-MIP sensors showed excellent reproducibility, reusability, stability, and durability. From the linear calibration curve in concentration ranging from 1 to 30 μg/mL, sensitivity of L-MIP sensor was significantly higher than planar-MIP (P-MIP) and non-imprinted polymer (NIP) sensors. In the selectivity test, the signal recoveries in the interference solutions were 101.8–109.8%, showing excellent accuracy. Based on these results, the MIP sensor shows great potential as a sensing tool for quantitative analysis of biomolecules.