Synthesis and Characterization of L-lysine Polyurethane(LPU) Nanoparticles for Drug Delivery
발표자
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초록
내용
To obtain biodegradable biomaterial for matrix of drug delivery, L-lysine polyurethane(LPU) was designed using the biodegradable triblock oligomer polylactide-poly(ethylene glycol)-polylactide(PLA-PEG-PLA) as a soft segment, 1,6-hexamethylene diisocyanate(HMDI) as a hard segment and L-lysine ethyl ester(LEE) as a chain extender. PLA-PEG-PLA was synthesized by ring opening polymerization(ROP) of lactide monomer onto poly(ethylene glycol) core and stannous octoate as a catalyst. LEE was synthesized by esterification of L-lysine with ethanol using thionyl chloride as a catalyst. LPU nanoparticles were fabricated by using water-in-oil-in-water double emulsion technique. The structure and composition of the resulting polyurethane was confirmed by 1H-NMR, 13C-NMR, FT-IR spectroscopies, and the molecular weights of polyurethane and PLA-PEG-PLA triblock were characterized by GPC. The morphology of nanoparticles was confirmed by DLS, FE-SEM and TEM.