Iodinated Nanoparticles as a Biodegradable CT Contrast Agent for Direct Imaging of Cerebral Thrombosis In Vivo
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초록
내용
Computed Tomography (CT) is one of the most used imaging techniques for ischemic stroke with high penetration depth and short operation time. Ischemic stroke occurs when a blood clot blocks a blood vessel leading to the brain, and permanent disability can be induced without perfusion in 3 hours from the outbreak of the stroke. While conventional molecular CT contrast agents can contrast blood vessel only, it is impossible to know the exact shape of the clot. MRI is necessary to figure out the property of clot, however, MRI is so expensive and the operation time is too long. Therefore, we suggest the iodinated organic nanoparticle as a biodegradable CT contrast agent. A water-soluble iodinated monomer was used with a biodegradable linker for renal clearance. Imaging was successful showing not only the location but the size and shape of the clot as well, even for a partially blocked blood vessel. In conclusion, we expect the iodinated nanoparticles to work as biodegradable CT contrast agents capable of imaging the clot with exact size and shape.