Hard Tissue-Emulating Directional Biomineralization for the Oral Microbiome Balancing Membrane
발표자
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초록
내용
The human retains a healthy microbiome balance. Given the diseased patients, competition within the bacterial community biases toward the bad, resulting in the bad bacteria-dominant microbiome. Currently, the fecal microbiota transplant is the representative microbiome balancing method. Here, we develop the hard tissue-emulating biomineralization to impart the microbiome balancing property. The directional mineralization of bone is emulated by selectively ion adsorbing zwitterionic layer. In particular, Ca2+-plane-rich mineral is obtained, balancing the microbiome by supplying nutrients. To prove the concept, ex vivo human saliva biofilm is grown on the directionally biomineralized membrane. The bacterial phylum and genus results indicate that the biofilm involves simple microbiome distribution, and a new community is not constructed. Furthermore, peritonitis-related bad bacteria are rarely observed, confirming the unique microbiome balancing property.