Hydrogels with Multi-functional Tannic Acid-Magnesium Nanoparticles for Osteoimmunomodulation and Vascularization
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초록
내용
Recent studies have emphasized the need for osteoimmunomodulation for bone regeneration and tannic acid(TA) has been known to modulate the immune system. While many studies exploited this property, most focused only on immunomodulation, indirectly boosting osteogenesis. This study developed a TA-Magnesium particle(TMgP) to directly enhance osteogenesis and angiogenesis via Mg2+, yet maintaining the effects of TA. TMgPs were assembled by the ability of TA to form a metal-phenolic network, then were associated with a gelatin gel(G-TMgP) to retain at the site of injury. G-TMgP reduced the expression of pro-inflammatory genes in macrophages. Furthermore, stem cells treated with G-TMgP showed higher levels of osteogenesis, evident by higher osteogenic gene expression and Ca2+ deposition. Angiogenic effects of G-TMgP were visualized by wound closure and tube formation. Finally, the curative effect of TMgP was confirmed in vivo, where the amount of regenerated bone was higher in TMgP groups.