Dynamic manipulation of ligand availability for immunoregulation of macrophages
발표자
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초록
내용
Dynamic manipulation of ligand availability controls receptor-ligand binding for macrophage adhesion-related immunoregulation. In this session, magnetically or photonically controllable reversible blocking, anchoring, and swelling of liganded materials to regulate ligand availability will be demonstrated. First, I will present magnetic nanoaggregates tethered over liganded surface to magnetically lift or drop the aggregates, thereby unblocking or blocking ligands to stimulate or suppress receptor-ligand binding, respectively. Next, I will demonstrate submolecular ligand size and spacing via template-mediated growth as well as magnetic anchoring of ligand regulate macrophage adhesion. Finally, photoswitchable microgel composed of azobenzene and liganded polymers that exhibit swelling or deswelling for enhanced or restrained ligand availability, respectively, will be shown. Further versatile use of proteins can offer dynamic and remotely controllable manipulation of diverse host cells.