Hydrogels-based Strategies to Therapeutic Applications
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In situ forming hydrogels have been widely used as injectable and sprayable therapeutic carriers and scaffolds for a wide range of biomedical applications, owing to their extracellular matrix mimicking properties and minimally invasive surgical procedure. Among various cross-linking methods to create in situ cross-linkable hydrogels, enzymatic method has attracted significant interest because of its mild reaction conditions, high efficiency, and substrate specificity. In our lab, we have developed horseradish peroxidase-catalyzed in situ forming hydrogels of various polymers for versatile biomedical applications, such as therapeutic delivery (peptides, proteins, growth factors, genes, virus, stem cells), and stem cell therapy for tissue regenerations. The hydrogel matrices were made of various synthetic and natural polymers, including PEO-PPO copolymers, gelatin, keratin, hyaluronic acid, chitosan and heparin. The wide-spread applications of injectable hydrogels will be discussed.