Targeted Drug Delivery Inspired by Real-Time Molecular Imaging
발표자
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초록
내용
Molecular imaging is recognized as a key technology for theragnosis which is known as an emerging paradigm for future personalized medicine. Polymer nanoparticles which have been used as a useful carrier for drug delivery system could also be served as an excellent imaging probe for molecular imaging. Approaches to combine these two important functionalities all together in a polymer nanoparticle are proposed in this presentation. In recent studies, we developed epidermal growth factor receptor (EGFR) and CD 47 receptor-specific self-quenched imaging probes, which can emit fluorescence (activate) via de-quenching reaction in lysosome, resulting in showing target-specific fluorescence signal in vitro as well as in vivo condition.