Antifouling coatings through Zr(Ⅳ)-mediated coordination of zwitterionic materials
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초록
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Surface hydration is an important factor for achieving antifouling coatings to suppress undesired adsorption of proteins and bacteria. In this study, we synthesized an amine-terminated zwitterion materials, sulfobetaine (SB), and introduced SB to solid substrates by a coordination-driven method to impart antifouling effect by inducing strong hydration on the surface. Titanium was used as a model substrate because it is widely employed as a medical material due to its excellent biocompatibility. As an initial adhesive layer, tannic acid film was firstly on titanium substrates through the complexation with ZrIV, followed by the anchoring of SB via ZrIV-mediated crosslinking. The antifouling effects of the zwitterion-coated substrates were evaluated against E. coli, S. aureus, and plasma rich platelet. Given that simplicity and versatility of the current approach, we believe that coordination-driven coating can be applied to various substrates used in medicine and daily life where antifouling effects are required.