Tamoxifen-selective Fluorescent Nanomaterials via Self-assembly Driven by the Structural Similarity of Tetraphenylethlyene Derivatives
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We report a simple co-assembly strategy for preparing tamoxifen-selective supramolecular nanomaterials in an aqueous solution. The synthetic amphiphiles contain 1,1,2,2-tetraphenylethylene (TPE) moiety that is selected as a tamoxifen-selective building block owing to its structural similarity with tamoxifen. The amphiphile molecule promotes the collapse of large tamoxifen aggregates into smaller aggregates such as ribbon-like and micellar assemblies, enhancing dispersion of the drug molecule. The TPE moiety also exhibits enhanced emission ability upon the interaction with tamoxifen, enabling the observation of the co-assembled species for cell imaging. The tamoxifen-selective fluorescent micelles show anticancer effects against breast cancer cells via the enhanced absorption of tamoxifen. These supramolecular approaches based on structural similarity can provide a novel strategy in the efficient development of selective molecular carriers with an understanding of the rational intermolecular interactions at molecular levels.