Graphene Quantum Dots-Imiquimod Loaded Dissolving Microneedle for Cancer Immunotherapy
발표자
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초록
내용
Immunotherapy with drugs containing microneedle has been actively researched. Researchers have showed various significant results with numerous drugs and methods such as imiquimod(IMQ), resiquimod(R848) and vaccination using ovalbumin(OVA) or DNA. However, there is a limit to the rapid treatment of tumors because the immune response occurs slowly. We used graphene quantum dots(GQD) that have photo-thermal therapy effect to treat tumors rapidly. Herein, we combined GQD and IMQ to see the effects of both immunotherapy and photo-thermal therapy, and delivered them using microneedle through the skin. GQD and IMQ bind to π- π stacking, which is expected to be able to efficiently transfer into cells because binding is broken at pH 5. We believe that this study could offer a promising approach to treat skin cancer effectively.