Systematic investigation to the effects of near infrared light exposure to polymeric micelles poly(ethylene glycol)-block-poly(styrene-alt-maleic anhydride) loaded with indocyanine green
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Recently, our group has developed near infrared release responsive drug delivery employing amphiphilic block copolymer loaded with indocyanine green and doxorubicin, then crosslinkedby diselenide bond to form polymeric micelles. The results demonstrated that the drug release can be controlled externally due to the cleavage of diselenide bond under near infrared exposure.However, we also found unexpected result which was the polymeric micelles continuously damagedeven 30 hours after near infrared exposure was stopped.Therefore, herein we provide a systematic investigation to this phenomenon. We found that the reactive oxygen species produced by indocyanine green not only attack the diselenide bond but also attack the polymer chain, resulting in polymer degradation.