DOPA is widely known for having strong and durable adhesion strength even in the water. One of the unique structure of L-3,4-dihydroxyphenylalanine(DOPA) containing catecholic amino acid, which is known to important part of adhesive and cohesive to mussel. In this study, copolymers with DOPA derivatives and various acrylic monomers were synthesized by free radical polymerization to improve the adhesion. Acrylic-grafted block copolymers (PEO-PPO-PEO) with various molecular weight were also successfully prepared. The incorporation of the DOPA has been successfully carried out and the analogues synthesized were characterized. We have developed the synthetic adhesives by blending of the DOPA derivatives containing acrylate groups or amino-sulfonate zwitterions and acrylic grafted block copolymers with cations for practical application even under water. The adhesion characteristics of copolymers with various blending ratio were compared.