An implantable fibrous platform modified with multiple stimuli-responsive polypyrrole for synergistic cancer therapy
발표자
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초록
내용
In this study we have developed a customizable fibrous site-specific drug-delivery platform functionalized with multiple stimuli-responsive polypyrrole (PPy) for the combination treatment via photothermal ablation and chemotherapy. Primarily, the drug-loaded polymeric electrospun mat was fabricated, followed by functionalization with stimuli-responsive materials. The resulting composite membranes were characterized by physicochemically and biologically. The final products exhibited excellent photostability and heating property in response to NIR exposure. PPy-coated mats exhibited enhanced drug release in a pH 5.5 environment compared to pH 7.4. The release was further accelerated in response to NIR under both conditions; however, the superior release was observed at pH 5.5 compared to pH 7.4, indicating a dual stimuli-responsive drug-delivery platform.