Improved Effect on Cervical Cancer-targeted Photodynamic Therapy by Excessive ROS Generation due to Cold Atmospheric Plasma Treatment
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Photodynamic therapy (PDT) is a promising tumor treatment modality and can convert oxygen into reactive oxygen species (ROS) by using photosensitizer under laser irradiation to suppress tumor growth. Generated ROS can cause significant toxicity leading to cell death via apoptosis. In this study, we explored the anti-cancer potential of PDT using pheophorbide a (Pheo a) as a photosensitizer in combination with 671 nm LEDs. Pheo a was encapsuled in micelles based on amphiphilic Poly(L-lactide–co-glycolide)–poly(ethylene glycol) (PLGA–mPEG) to improve its solubility and permeability. Also, for developing photosensitizers with enhanced PDT efficacy, HPV E7 peptide (TLGIVCPI) with specific cervical cancer targeting properties was used as the targeting ligand. In addition, cold atmospheric plasma (CAP) was applied to the cervical cancer therapy to improve therapeutic efficacy. Finally produced micelle can lead to high cancer cell death rate through PDT and CAP combination therapies.