Development of Cationic Polyester-Co-Polypropylene Glycol Di-Block Copolymer By One-Pot Anionic Ring Opening Polymerization
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초록
내용
In this present investigation, a cationic polyester-co-neutral poly propylene glycol (CPE-PPG) di-block copolymer has been synthesized by a one-pot reaction method. In the first step, anionic ring opening polymerization of 3-(t-BOC amino) 1,2 propylene oxide and succinic anhydride was carried out and in the second step, propylene oxide was injected to build poly propylene glycol block on the reactive anionic site to get poly(t-BOC amino propylene succinate)-co-polypropylene glycol diblock copolymer. After deprotection of t-BOC group, arginine was attached on free amine group of polymer backbone to get CPE-PPG. The polymer was characterized by FTIR, NMR, zeta potential and GPC analyses. The cationic CPE-PPG/heparin coacervate microparticles were prepared and their colloidal stability has been investigated by DLS size measurement. This investigation provides a simple method for synthesizing cationic block copolymers for biomedical applications.