Characterization of pendant group-functionalized polycaprolactone for temperature-responsive hydrogels and biomaterial engineering
발표자
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초록
내용
In biomaterial engineering, Polycaprolactone have attracted attention for temperature-responsive hydrogels functionality. In this study, we manufactured 4-benzyloxy-caprolactone (CL-OBn) to graft functional group to PCL and then ring opening polymerization was performed by using the hydroxyl group of methoxy polyethylene glycol (MPEG). We expected that it could be used as a biomaterial by using an acid catalyst which can be removed easily. The MPEG-PCL with benzyl pendant group (MC-OBn) was deprotected and replaced with a hydroxy group to finally produce MC-OH. The molecular weights and segment ratios of MC-OH were close to the theoretical values. Suspension of MC-OH was observed distinct sol-to-gel phase transitions as a function of the temperature and relied on the amount of pendant group. As a result, we demonstrated that functionalized polycaprolactone were successfully obtained and served as temperature-responsive hydrogels for biomaterial engineering.