Cytotoxicity and antibacterial activity of poly(acrylic acid) hydrogel containing metronidazole for a versatility of drug delivery system
발표자
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초록
내용
Poly(acrylic acid) (PAAc) hydrogel films have a good bioadhesive property and is able to localize the absorption site and increase the drug residence time. Metronidazole (MD) is a nitroimidazole compound that has been widely used for treating infections caused by anaerobic bacteria and otitis media. In this study, PAAc and MD mixtures were exposed to γ-radiation, and MD containing PAAc hydrogels were verified by biological characterization such as cytocompatibility and antibacterial activity for inhibiting the growth of Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), and Streptocaccus mutans (S. mutans). The MD/PAAc hydrogels exhibited no cytotoxicity and good antibacterial activity