Enhanced modified Agarose hydrogels with Resveratrol for Retinal Pigment Epithelial cells regeneration
발표자
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초록
내용
Agarose (Agr) is a purified linear galactan hydrocolloid isolated from agar or agar-bearing marine algae. It is biocompatible and it has temperature sensitivity to solidify at body temperature and in liquid state at high temperature. Resveratrol (RSV) is a polyphenol phytoalexin, which found in the skin of berries and peanuts. It has anti-oxidant, anti-inflammatory, anti-epithelial-mesenchymal transition and anti-proliferative roles through sirtuin. Cylindrical RSV/Agr hydrogels were prepared with 0, 5, 10, 20, 30 and 50w% RSV with 3w% Agarose. The characteristics of the RSV/Agr hydrogel were analyzed by Fourier transform infrared spectroscopy (FT-IR), porosity and water uptake, compressive strength and scanning electron microscopy (SEM). As a result, the higher the content, the denser and more numerous pores were formed. In future, the in vitro test using rabbit retinal pigment epithelial cells will be studied.