Biomecial applicationa of Curcumin for cancer therapy
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초록
내용
Curcumin (CRC) has been widely used as a therapeutic agent for various drug delivery applications. We used curcumin as a drug delivery vehicle as well as therapeutic cancer agent. In the first part, we focused on the applicability of CRC as a drug delivery vehicle for doxorubicin (DOX) coated with poly-(ethylene glycol) (PEG) as an effective therapeutic strategy against multidrug-resistant cancer cells. The nanocomplexes were well localized within the resistant cancer cells inducing apoptosis and suppressed the tumor growth. In the second part, we developed novel hyaluronic acid cross-linked zein nanogels (HA-Zein NGs) to deliver the potential anticancer agent curcumin. The CRC encapsulated HA-Zein NGs were found to exert a specific toxicity against CD44 positive cancer cell (CT26 tumor cell) in vitro. The in vivo bio-distribution with a CT26 tumor model showed their high tumor accumulation thereby improved antitumor efficacy with a low dosage of CRC.