From Basics to Applications for Polymer Industry (영어발표)
발표 구분
초청강연
제목
Globular Proteinosome: Next-Generation Synthetic Vesicle Self-Assembled from Recombinant Fusion Proteins
발표자
()
초록
내용
Vesicles containing functional globular proteins have enormous potential different from traditional liposomes or polymersomes. The soluble fusion protein mixtures, composed of a globular domain fused with a glutamic acid-rich leucine zipper and an arginine-rich basic leucine zipper fused with an elastin-like polypeptide, self-assemble into hollow vesicles upon warming through a dynamic coacervation. We suggest a simple strategy to engineer membrane structure and composition of globular proteinosomes with the desired size towards advanced synthetic vesicles. The main parameter to decide the final vesicle structure is the thermal driving force behind the vesicle assembly that affects the molecular packing parameter, which enables the formation of either single-layered or double-layered vesicles. We also create heterogeneous vesicle membranes containing multiple globular domains by tuning the intermediate coacervate phase based on a fundamental kinetic study in the phase transition.