A 3D printed PLCL/dECM hydrogel complex for adipose tissue engineering.
발표자
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초록
내용
Adipose tissue regeneration has been studied, however, many disadvantages such as fast degradation rate and mismatch of mechanical properties still exist. So we set up several strategies to overcome these limits. Poly (L-lactide-co-ε-caprolactone) (PLCL) was synthesized to provide proper mechanical properties and a stable tertiary structure. Decellularized extracellular matrix (dECM) was used to promote angiogenesis for efficient blood supply. 3D printing was used to fabricate a patient-specific scaffold. The PLCL and hydrogel was printed through dual nozzle system. Flexibility and stretchability of the PLCL were maintained after 3D printing. In vivo experiments were conducted to investigate the potential for adipose tissue regeneration (PLCL only, PLCL-Hydrogel complex). We evaluated the mechanical properties, morphologies and gene expression level for scaffold characterization. We expected our constructs will be a promising alternative for adipose tissue regeneration.