High-intensity Focused Ultrasound-triggered Drug Delivery using Conformationally Transformable Peptide
발표자
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초록
내용
Ultrasound-based thermosensitive liposomes have been in the spotlight for cancer therapy because of the possibility of controlled, efficient drug delivery. However, thermal vascular damage after hyperthermia treatment by high intensity focused ultrasound (HIFU) may decrease drug release into tumor tissue and affect the therapeutic efficacy. To overcome this limitation, we designed doxorubicin (DOX)-loaded thermosensitive liposomes (DOX-FTSLs) which can site-specifically release the drugs in response to non-thermal ultrasound using elastin-like peptide. Then, we compared in vivo behavior of DOX-FTSLs with two of different ultrasound conditions. Interestingly, higher tumor tissue penetration of DOX-FTSLs occurred without vascular damage by non-thermal acoustic treatment. The results demonstrated the possibility of safe thermosensitive liposomes for cancer therapy.