Impartment of antibiofouling properties to macro and nanoscale gold sufaces by utilizing simple synthesis and coating method of sulfobetainic zwitterionic small molecule.
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The goal of this study is to develop a one-pot synthesis of a zwitterionic small molecule and use it as an effective anti-biofouling coating material on macro and nanoscopic gold surfaces. To this end, a zwitterionic small molecule was successfully synthesized by a one-pot method using dipyridyl disulfide. The coating conditions and stability were examined through contact angle measurements, surface plasmon resonance (SPR), X-ray photoelectron spectroscopy. The anti-biofouling properties of the coated gold surface were analyzed by FITC-bovine serum albumin (BSA) test and SPR as contacting with BSA solution. In addition, the effect of zwitterion-coating on stability of and protein adsorption on gold nanoparticles were examined through a NaCl stability test and BSA adsorption test, respectively. As a result, simply synthesized zwitterionic small molecule effectively enhanced the anti-biofouling properties gold surfaces and the salt stability of gold nanoparticles.