N-Heterocyclic Carbene Ligands Conjugated with Nanohybrids for Biosensors
발표자
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초록
내용
N-Heterocyclic carbenes (NHC) as a novel class of ligands have appeared particularly relevant for the stabilization and functionalization of the surface of materials. Through the physiochemical stability of the NHCs, we synthesized novel NHC derivatives connecting the functional groups as an amine, acid, and azide at the end of the molecule, which were able to stably link with bio-receptors as well as improve sensor performance and reproducibility. The synthesized NHCs were powerfully bonded with various nanomaterials, such as gold nanoparticle and graphene. The NHCs-nanohybrids were then purified and characterized using XPS, IR, TEM, and spectroscopic techniques. The nanohybrids are stable in diverse aqueous solutions in the wide range of pH and in 0–1000 mM electrolyte solutions, at high and low temperature. These stable nanohybrids were conjugated with bio-receptor to detect the infectious disease.