Phosphorylcholine surface modified mesoporous silica nanoparticles for sustained drug release
발표자
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초록
내용
Phosphorylcholine surface modified MCM41 mesoporous silica nanoparticles (MSNs) were prepared by post condensation method. Phosphorylcholine groups were generated by the ring-opening reaction of 2-chloro-2-oxo-1,3,2-dioxaphospholane (COP) subsequent to 3-bromopropyl triethoxy silane immobilization. Modified nanoparticles were characterized by Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, small-angle X-ray scattering (SAXS), SEM, TEM and N2 adsorption-desorption analyses. Phosphorylcholine modified MSNs were found to have well-ordered meso-structural integrity and morphology of MCM41 with some reduction in their pore size and pore volume. The drug molecules were loaded effectively onto phosphorylcholine modified silica nanoparticles. The drug-loaded MSN-PC showed the sustained release of alendronate molecules under physiological pH conditions (pH 7.4).