Synthesis and Characterization of Hydrogen Peroxide Sensitive Diselenide Compound
발표자
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초록
내용
ROS is essential for the homeostasis because it is involved at biological metabolism. However, over-expressed ROS is a major cause of aging and inflammation and it causes diseases such as rheumatoid arthritis, diabetes and Alzheimer's. Selenium is also a one of the essential nutrient as antioxidant for remove of excess H2O2, which is one of the ROS. In this study, we synthesized diselenide compound containing small molecules (diSe-SO4) and confirmed by 1H-NMR. The diselenide bond is effective antioxidant because it is easily oxidized by H2O2 and decreased level of H2O2. The H2O2 sensitivity of diSe-SO4 was characterized by FT-IR, UV-vis, and XPS. In conclusion, the diSe-SO4 was sucessfully synthesized and purification. The H2O2 sensitivity of purified diSe-SO4 was confirmed by FT-IR, UV-vis, and XPS. Cell viability (＞90%) was confirmed in MRC-5 cells via CCK-8 and FACS analysis. Thus, diSe-SO4 is expected to be successfully used at various diseased as an antioxidant.