Membrane penetrating polyeletrolytes for effective intracellular drug delivery
발표자
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초록
내용
For effective intracellular delivery of drugs, this study designed low molecular weight (LMW) branched poly(ethylenimine) (bPEILMW)-based high molecular weight (HMW) reducible polyelectrolytes having either primary amines or carboxylic acids at hydrophilic peripheral area. These reducible polycation (RPC) and reducible polyanion (RPA) efficiently loaded hydrophobic doxorubicin (DOX) because their inner compartments with secondary and tertiary amines are hydrophobic. Both DOX-loaded RPC (DOX@RPC) and DOX@RPA represented 3-fold and 100-fold higher killing effects than free DOX‧HCl in HCT116 cells and NCI/ADR-RES cells, respectively. Especially, these polyelectrolyte-based drug delivery systems exhibited cell membrane penetrating pathway unlike endocytic pathways of most nanosized drug carriers. In conclusion, the designed RPC and RPA could be potentials for effective intracellular delivery carriers of hydrophobic therapeutics.