Enhanced singlet oxygen generation ability via ancillary ligand tuning of Iridium complexes
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Photosensitizers and their singlet oxygen generation abilities have widely been studied for various applications such as phtotodynamic therapy (PDT) and photosynthesis. However, an in depth design strategy of an efficient organometallic photosensitizer is yet to be clear. Herein, iridium photosensitizers containing 2-phenylquinoline as a main ligand but different ancillary ligands have been analyzed in terms of their photophysical properties, singlet oxygen generation and in vitro cancer cell suppression abilities. Interestingly, Ir-bphen showed a remarkable singlet oxygen generation ability in spite of its relatively low PL intensity and quantum yield. Its supreme reactive oxygen generation capability was shown in following cell tests. The results somewhat contradict our general knowledge that a higher quantum yield leads to a better PDT effect and thus highlight the importance of further complicated studies on energy transfer pathway to oxygen.