Lipid nanoparticles loaded with Bambusae Caulis in Taeniam extract with anti-inflammatory activity.
발표자
()
초록
내용
Bambusae Caulis in Taeniam extract (BCT) was loaded in lipid nanoparticle including decanoyl alginate (DeAlg) and decanoyl gelatin (DeGel). Transmission electron microscopy (TEM) showed that the water channel was black and the lipid layer was white. The lipid nanoparticle exhibited a restrained release of BCT at an acidic condition (e.g. pH4.5), possibly due to DeAlg/DeGel coacervate. The survival rate of the cells (RAW 264.7) stimulated with fine dust was higher than that of free BCT with lipid nanoparticles containing BCT. When the lipid nanoparticles loaded with BCT were treated with cells stimulated with fine dust, the amount of prostaglandin E2 (PGE2) expression was similar to that of dexamethasone (an anti-inflammatory agent) treated cells. The degree of cellular internalization of lipid nanoparticles observed by fluorescence-activated cell sorting (FACS) and confocal laser scanning microscopy (CLSM) was found to be effective.