Development of retinol formulation with improved stability using polymeric micelle nanoparticles
발표자
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초록
내용
Retinol is a representative compound of vitamin A, which has the effect of increasing the elasticity of the skin, but it is difficult to be applied due to its low solubility and low stability in external environment. In this study, the biocompatible polymers and natural antioxidants were used to make retinol as polymer micelle nanoparticles to improve the solubility and stability in external environments. The particle size of prepared micelle nanoparticles were evaluated by ELS-Z and to evaluate the long-term stability of micelle nanoparticles, visual evaluation, particle size, HPLC, and UV spectrophotometer were used. For stability evaluation, retinol micelle nanoparticles were kept during 3 months at various temperatures. Three months of study have shown that no discoloration or precipitation of retinol occurred and the changes in particle size and contents were also rarely occurred. It is expected that retinol can be used as an excellent cosmetic material by using polymeric micelle.