Formation and Characterization of Dequalinium Emulsion as a specific Drug Carrier for mitochondrial Diseases
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초록
내용
In the previous study, we confirmed possibility of dequalinium liposomes as a mitochondrial targeting carrier. However, dequalinium liposomes showed poor physical stability when drug molecules were loaded to liposomes. we prepared dequalinium emulsion. we evaluated physical properties through analysis technique such as DLS, zeta potential, TEM and AFM, and biological properties. Dequalinium emulsions showed good mitochondrial targeting capacity, and it implies that dequalinium emulsion has potential for efficient mitochondrial therapy by solving stability problems.