Organelle control strategy of anticancer drug nano-carriers with mitochondrial targeting and glutathione-triggered release
발표자
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초록
내용
To maximize therapeutic effects of drugs delivered by drug delivery systems, this study designed functional components for mitochondria-targeted drug delivery and drug release. To pursue these aims, triphenylphosphonium (TPP) as a mitochondrial targeting moiety and disulfide bonds as a GSH-sensitive drug release were selected. The designed carrier was TMSPCL polymer-based nanoparticles (NPs) and the polymer was composed of TPP and poly(ε-caprolactone) (PCL) with multiple disulfide bonds (MSPCL). TMSPCL NPs loaded efficiently hydrophobic doxorubicin (DOX), resulting in formation of DOX@TMSPCL NPs with up to 13 wt%. In MCF7 and MCF7/ADR-RES cells, DOX@TMSPCL NPs showed 3.2-fold and 175.4-fold better cell-killing activities than free DOX, respectively. DOX@TMSPCL NPs efficiently targeted to mitochondria and then released their payload in mitochondria. In conclusion, the designed carrier could have a potential for mitochondria-targeted delivery and release of payloads.