Selective Multiplexing of Trace-amount Molecules via SERS using Thermally Soldered Au Nanogrids with Enhanced Plasmonic Resonance
발표자
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초록
내용
In molecular sensing, multiplexing can significantly reduce analysis time, save sample volume, and provide more thorough information. So far, multiplexing is realized through assays based on highly sensitive fluorescent or electrochemical response, yet lack in specific differentiation and selective recognition. Surface-enhanced Raman spectroscopy (SERS) has recently drawn much attention owing to its fingerprint-spectra specificity and single-molecule level sensitivity. However, conventional approaches are either costly, time-consuming, or lack in reproducibility. Herein, we present thermally soldered Au nanogrids for multiplexing of trace-amount toxins in drinking water. The Au nanogrids are highly stable during ssDNA aptamer functionalization and also show reduced grain-boundaries and enhanced plasmonic quality. Singular and multiplex detection results of trace-amount bisphanol A, tetracycline, and diclofenac show high sensitivity, specificity, and selectivity in mixed samples.