Advanced Transarterial Chemoembolization using Magnetic Janus Microparticles with Anti-Angiogenetic Drugs for Liver Cancer
발표자
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초록
내용
The majority of the causes of liver cancer is due to HCC (hepatocellular carcinoma), which is difficult to diagnose early. Transarterial chemoembolization (TACE) is one of methods for treatment of liver cancer, which induce necrosis of cells by injecting catheter into the hepatic artery and sending microparticles that can block blood vessels connected with cancer cells. Although TACE is very effective method for unrespectable HCC with prolong survival, recurrence of tumor by angiogenesis is inevitable. Here, we prepare polymeric Janus microparticles with two compartments, which one is polycaprolactone-rich phase and the other is poly(lactide-co-glycolic acid)-rich phase. To apply magnetic anisotropy and the synergistic effects, iron oxide nanoparticles and anti-angiogenetic drugs are added into microparticles. The motions-induced by the magnetic field enables the active drug-release and results in the use of the microparticles for the promising therapeutic tools to cancer treatment.