Preparation of an injectable hydrogel derived from porcine articular cartilage as a biomedical material.
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Injectable hydrogels are promising substrates for therapeutic applications, owing to their targeted delivery by minimally invasive techniques and their ability to easily fill defects in tissues. Comparing to synthetic materials, natural materials are often preferred to use as injectable hydrogels due to their unique properties. Among various candidates for natural materials, the natural material derived from porcine articular cartilage is composed of an extracellular matrix. The extracellular matrix called cartilage acellular matrix (CAM) gives a short biodegradation period and poor mechanical properties. However, CAM provides not only high biocompatibility but also an environment in which the cells can survive, supplying the growth factors necessary for cell growth and differentiation. To overcome the drawbacks of the material, we prepared CAM as a degradation period and mechanical property adjustable injectable hydrogel through a biochemical cross-linking reaction.