Reductive Cleavage of the Azo Bond: An Opportunity for the Development of Enzyme Sensitive Molecules and Materials
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초록
내용
The azo linkage (N=N) is one of the very few functional groups in organic chemistry that exhibit sensitivity towards thermal, chemical, photochemical, and biological stimuli. As a consequence, each property has given rise to a distinct class of organic materials. For example, thermal sensitivity has led to free radical initiators useful in curing and polymerization applications. Chemically induced cleavage such as with sodium dithionite has aided the development of reactive scaffolds for proteomics applications. Photo-isomerization capability has given rise to photo-responsive materials. In this presentation, our aim will be to show that azo bond scission under biologically reducing environment, such as that of colon as well as under hypoxia conditions, presents a new opportunity in the development of responsive and functional soft materials.