Near-infrared-triggered photodynamic therapy with multifunctional upconversion nanoparticles.
발표자
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초록
내용
Lanthanide-doped upconversion nanoparticles (UCNPs) can emit high-energy visible light by absorbing low-energy NIR light via upconversion process. UCNPs is a substance that can activate adjacent photosensitizer (PS) for photodynamic therapy (PDT) through fluorescence resonance energy transfer (FRET). Also, compared to conventional fluorescent materials, UCNPs do not have auto-fluorescence, which greatly improves signal-to-noise and the sensitivity of detection. In this study, UCNPs were synthesized under various conditions by thermal decomposition method to investigate the photoluminescence efficiency according to size and shape. Their surface modification was conducted for PDT application. Finally, PDT action of surface-modified UCNPs were determined by singlet oxygen generation with 980 nm NIR laser.