TA-functionalized gold nanoparticle bioseonsor chips for rapid and reliable detection of biomolecules.
발표자
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초록
내용
With the recent advances in nanotechnology, nanoparticles have received great interests in the field of biosensors due to their exquisite sensitivity in chemical and biological sensing. Tannic acid (TA) is a kind of plant-derived compounds and is one of the most abundant polyphenols including five gallol groups and five catechol groups. Furthermore, TA has strong affinity with biomolecules such as DNA, glycoprotein, proline-rich protein, forming multiple hydrogen bond and hydrophobic interaction between TA and biomolecules. In this study, surface-modified gold nanoparticles with TA were prepared to bind various biomolecules for biosensor applications. In addition, biosensoric devices were fabricated by using PDMS substrate. Their physicochemical properties and binding ability were evaluated.