Poly(ε-caprolactone)-b-poly(L-lactic acid) Microspheres via UV Photodegradation and RAFT Polymerization
발표자
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초록
내용
Biodegradable triblock copolymers based on polycaprolactone (PCL) were synthesized by ring opening polymerization of PLA followed by RAFT polymerization of poly(methyl vinyl ketone)(PMVK). Microspheres based on triblock copolymers were prepared by emulsion-evaporation method, and then photodegraded with UV irradiation to obtain porous microparticles. In order to polymerize by RAFT method, PCL-PLA based macro-CTA (chain transfer agent) was first synthesized by reacting carboxylic acid-terminated CTA with PCL-PLA, and used to synthesize triblock copolymer with methyl vinyl ketone (MVK). The morphology of the particles before and after UV irradiation were confirmed by SEM and confocal images and the release studies of paclitaxel, anti-cancer agent for female cancers from the particles were evaluated by HPLC. PCL-PLA based biodegradable microparticles will be anticipated to enhance drug release and could find potential application for biomaterials.