Nitrogen Containing PAG Photochemically Induced Singlet Oxygen via New Mechanistic Pathway
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Singlet oxygen generators containing conjugated aromatic groups or heavy metal atom have shown good efficacy in photodynamic therapy, however, most of them displayed limitations as therapeutic agents due to poor biocompatibility. Herein, we introduce a new type of singlet oxygen generator based on aliphatic polyaminoglycerols (PAG) with superior biocompatibility. It was confirmed that nitrogen atom on the backbone of PAG was responsible for the electron transfer owing to its paramagnetic properties that generates radical oxygen species, and subsequently converted to singlet oxygen.