Preservation of transplanted ovarian tissue by promoting angiogenesis and oxygen-enriched fibrin hydrogel
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The success rate of chemotherapy and survival rate of the cancer patients have increased over the decades by improvement of biomedical technologies; however, severe ovarian failure after chemotherapy can occur to female patients due to its high gonadotoxicity. Ovarian cryopreservation is one of the ways of facilitating fertility preservation to increase the quality of life in cancer survivors. Immediately after transplantation, ovaries are under ischemic condition due to lack or vascular anastomosis between the graft and host tissue. The transplanted ovaries can be damaged due to lack of oxygen and nutrients and result in necrosis and dysfunction. To prevent ischemic damage and accelerate angiogenesis, the ovary was encapsulated in oxygen-enriched fibrin hydrogels with the growth factor embedded PLGA nanoparticles. Thus, the oxygen and growth factor can complementary interactions to preserve and retrieve ovarian functions with angiogenesis.