Fabrication and Characterization of Carboxylic β-Cyclodextrin with Vitamin E/C
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α–Tocopherol(α-TO) has the highest antioxidant and biological activity and can be used in cosmetic, pharmaceutical, and food industry. Also, Vitamin C, known as L-ascorbic acid (AA) has bioactivity and anti-oxidation property. However, α-TO and AA are readily oxidized by light, air, oxidizing agents or heat, resulting in the reduction of their antioxidant value. Cyclodextrin (CD) can enhance the solubility and chemical stability of compounds in aqueous solution leading to increase the bioavailability. In this study, the oxidized β-CD, carboxy-β-CD was synthesized from TEMPO, NaBr, NaClO4. C-β-CD was used to synthesize the conjugation with α–tocopherol C-β-CD-TO) by using DCC and DMAP and and characterized by FT-IR, 1H-NMR, 13C-NMR spectroscopies. The inclusion complexes of β-CD with AA or α-TO were synthesized in H2O and characterized by FT-IR, UV-Vis spectroscopies, and DSC.