Plant derived polymer-based drug microcarriers degraded by pH- and enzymatic-dependent manners
발표자
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초록
내용
The plants derived polymers have been used for biomedical applications because of their numerous effects. Due to its high mechanical property, especially for cell wall extraction material, it is desirable for use in a drug delivery system (DDS) to maintain the high durability without any drug leakage issue in body. In this study, we prepared high durable DDS carriers using tannic acid (TA) and lignin which are extracted from green tea and cell wall, respectively. By using Layer-by-layer assembly (LbL), we have fabricated TA and lignin multilayer microcarriers. The TA and lignin carriers were stable at physiological condition for 7 days, started to degrade when enzyme treated. We controlled film degradation and drug release kinetics enzymatically and pH-dependent. TA and lignin carriers did not show cytotoxicity and have anticancer effect. We developed a smart drug delivery carrier using plant cell extracts that can be controlled via enzymatic effects, which is useful as DDS platform.