Nitric oxide delivery of nanoparticles coated with amine-rich polymer for the treatment of bacterial keratitis
발표자
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초록
내용
Bacterial-infected keratitis is a common disease. However, if it is not treated on time, it can cause severe symptoms such as blindness. Nitric oxide (NO) is a double-edged sword in terms of functions according to the concentrations. At high level of NO has killing effects against bacteria and cancer cells. On the other side, low level (below μM) of NO performs as a cell signaling molecule which regulates various physiological functions including wound healing. Since various therapeutic functions of this attractive gas molecule, we developed NO-releasing nanoparticle as a challengeable drug delivery system. The release behavior of NO was controlled based on a straightforward design which is surface-modified silica nanoparticles with amine-rich polymer. N-diazeniumdiolate, generated from amine, was slowly decomposed to NO gas due to stabilization by near unconverted amine groups. Based on this release property, the nanoparticle was effective on the treatment of bacterial keratitis.