Porous Matrices with Leaf-Stacked Structure for Tissue Engineering Applications
발표자
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초록
내용
Tissue engineering technique based on cells, scaffolds, and bioactive molecules to regenerate damaged tissues/organs have been extensively investigated. Sustained release of bioactive molecules from delivery systems is a common strategy for ensuring their prolonged bioactivity and for minimizing safety issues. However, residual toxic reagents, the use of harsh organic solvents, and complex fabrication procedures in conventional delivery systems are considered enormous impediments toward clinical use. Herein, we developed unique porous matrices with leaf-stacked structure which can allow sustained release of bioactive molecules and also stimulate target tissue regeneration using clinically feasible materials and procedures. Their bioactive molecules release behavior, differentiation of stem cells and target tissue regeneration (i.e., bone, cartilage, fat, blood vessel, etc.) in animal models were investigated.