Preparation and Characterization of Chitosan-coated PLGA nanoparticle
발표자
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초록
내용
The amphipathic PLGA is a FDA-approved to biocompatibility polymer. It is broadly used as drug delivery carrier of insoluble drugs. However, PLGA nanoparticle in oral delivery system has many problem including unstable particle and inefficient absorption in intestinal mucosa. To overcome these obstacle, chitosan was coated to PLGA nanoparticle, which may lead to enhanced bioavailability. Chitosan-coated PLGA nanoparticle (CPN) was prepared by w/o/w emulsion method. Its chemical structure was analyzed by 1H-NMR and FT-IR. In addition, its particle size and zeta potential were measured by DLS. Moreover, morphological property of CPN was observed by TEM. The thermal analysis of CPN was confirmed by TGA and DSC. Besides, cytotoxicity of CPN were assessed by MTT assay. These results suggest that CPN is superb drug carrier in oral delivery system. (No. NRF-2016H1D5A1910499).